Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30861113 | 0.89 | TEAD2 (0.45) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL30861065 | 0.89 | TEAD2 (0.45) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL1430083 | 0.88 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL19436553 | 0.88 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL1431721 | 0.84 | RAB9A (0.50) | ALDH1A1KDM4EHPGDGAATSHR | |
| SCHEMBL2417874 | 0.84 | KDM4E (0.44) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL23666053 | 0.84 | MAPK1 (0.45) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL23750872 | 0.84 | ALDH1A1 (0.42) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL24102981 | 0.82 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDGAAMAPK1 | |
| SCHEMBL22125767 | 0.82 | ALDH1A1 (0.41) | ALDH1A1KDM4EHPGDGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10967078-B2 | Radiolabelled mGluR2 PET ligands | JANSSEN PHARMACEUTICA NV (BE) | 2021-04-06 | — | — | US | disclosed |
| US-10220032-B2 | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2019-03-05 | — | — | US | disclosed |
| US-20180222908-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2018-08-09 | — | — | US | disclosed |
| US-20170273976-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10220032-B2 | 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of mGluR2 receptors | GRM2, GRM5, GRM1 | ALDH1A1 3536/4885KDM4E 2024/4885HPGD 1610/4885 |
| US-10967078-B2 | Radiolabelled mGluR2 PET ligands | GRM2, GRM3, GRM1 | ALDH1A1 4518/4885KDM4E 2567/4885HPGD 2489/4885 |
| US-20170273976-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM5, GRM1 | ALDH1A1 3951/4885KDM4E 2069/4885HPGD 1972/4885 |
| US-20180222908-A1 | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM5, GRM1 | ALDH1A1 3951/4885KDM4E 2069/4885HPGD 1972/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.