Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.31 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1093647 | 0.84 | TLR8 (0.42) | TLR8TLR7KDM4EGLA | |
| SCHEMBL19398238 | 0.83 | TLR8 (0.49) | RECQLALDH1A1HTTMEN1KMT2A | |
| SCHEMBL19398240 | 0.80 | TLR8 (0.54) | TLR8TLR7 | |
| SCHEMBL18759358 | 0.79 | TLR8 (0.35) | TLR8TLR7 | |
| SCHEMBL1235939 | 0.75 | TLR8 (0.48) | RECQLTLR8SMN1; SMN2NPC1 | |
| SCHEMBL12237688 | 0.73 | SRD5A1 (0.44) | ALDH1A1MYCNR4A1MEN1KMT2A | |
| SCHEMBL10325465 | 0.72 | KDM4E (0.39) | ALDH1A1TLR8TLR7KDM4ESMN1; SMN2 | |
| SCHEMBL3093660 | 0.70 | SRD5A1 (0.40) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL10326443 | 0.67 | CMA1 (0.51) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL31259524 | 0.67 | CMA1 (0.51) | ALDH1A1HTTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194735-A1 | Sulfinylphenyl or Sulfonimidoylphenyl Benzazepines | HOFFMANN LA-ROCHE INC. (US) | 2018-07-12 | — | — | US | disclosed |
| US-9890124-B2 | Benzazepine sulfonamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275253-A1 | BENZAZEPINE SULFONAMIDE COMPOUNDS | TLR8, TLR7, TLR5 | RECQL 3762/4885SIRT5 663/4885RXFP1 207/4885 |
| US-20180194735-A1 | Sulfinylphenyl or Sulfonimidoylphenyl Benzazepines | TLR1, TLR4, TLR5 | RECQL 2822/4885SIRT5 2073/4885RXFP1 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.