Sugi Predict

Sugi Predict / Compounds / SCHEMBL1235939

SCHEMBL1235939

SCHEMBL1235939

CC(C)(C)OC(=O)NC1=Nc2cc(Br)ccc2C=C(C(=O)O)C1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TLR8 Q9NR97 1/20 0.48
▸ BCL2 P10415 7/20 0.35
▸ BACE1 P56817 3/20 0.35
▸ BECN1 Q14457 3/20 0.35
▸ AAK1 Q2M2I8 6/20 0.35
▸ NPC1 O15118 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ LCK P06239 1/20 0.32
▸ BRD9 Q9H8M2 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30006352 1.00 TLR8 (0.48) TLR8BCL2BACE1BECN1AAK1
SCHEMBL21098295 0.87 TLR8 (0.48) TLR8NPC1RAB9ABRD9
SCHEMBL2333056 0.87 TLR8 (0.51) TLR8BCL2BACE1BECN1AAK1
SCHEMBL16592818 0.85 TLR8 (0.41) TLR8BCL2BACE1BECN1AAK1
SCHEMBL17843455 0.84 TLR8 (0.68) TLR8
SCHEMBL27175788 0.81 TLR8 (0.36) TLR8AAK1LCK
SCHEMBL16592799 0.79 TLR8 (0.42) TLR8BCL2BACE1BECN1AAK1
SCHEMBL1238110 0.79 TLR8 (0.55) TLR8
SCHEMBL28467264 0.79 BACE1 (0.37) TLR8BCL2BACE1BECN1AAK1
SCHEMBL18759358 0.78 TLR8 (0.35) TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2940009-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VentiRx Pharmaceuticals, Inc. (US) 2015-11-04 — — EP claimed
EP-2358683-B1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS INC (US) 2015-04-01 — — EP claimed
US-8314090-B2 Methods of synthesis of benzazepine derivatives VENTIRX PHARMACEUTICALS, INC. (US) 2012-11-20 — — US claimed
EP-2358683-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES Ventirx Pharmaceuticals, Inc. (US) 2011-08-24 — — EP claimed
US-20100216989-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS, INC. (US) 2010-08-26 — — US claimed
WO-2010054215-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS, INC. (US) 2010-05-14 — — WO claimed
US-20240299572-A1 NITROGEN-CONTAINING COMPOUND, CONJUGATE CONTAINING SAID COMPOUND, AND APPLICATION THEREOF Shanghai De Novo Pharmatech Co., Ltd. (CN) 2024-09-12 — — US disclosed
CN-117801107-A Benzazepine derivatives, conjugates containing same and application thereof 上海迪诺医药科技有限公司 2024-04-02 — — CN disclosed
EP-4342884-A1 NITROGEN-CONTAINING COMPOUND, CONJUGATE CONTAINING SAID COMPOUND, AND APPLICATION THEREOF Shanghai de Novo Pharmatech Co., Ltd. (CN) 2024-03-27 — — EP disclosed
CN-115448917-A Nitrogen-containing compound, conjugate containing nitrogen-containing compound and application of conjugate 上海迪诺医药科技有限公司 2022-12-09 — — CN disclosed
WO-2022242724-A1 NITROGEN-CONTAINING COMPOUND, CONJUGATE CONTAINING SAID COMPOUND, AND APPLICATION THEREOF 上海迪诺医药科技有限公司 2022-11-24 — — WO disclosed
EP-3949969-A2 BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF Silverback Therapeutics, Inc. (US) 2022-02-09 — — EP disclosed
EP-3595668-B1 BENZAZEPINE COMPOUNDS, CONJUGATES, AND USES THEREOF SILVERBACK THERAPEUTICS INC (US) 2021-07-21 — — EP disclosed
US-20110118235-A1 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VENTIRX PHARMACEUTICALS, INC. (US) 2011-05-19 — — US disclosed
US-20110092485-A1 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VENTIRX PHARMACEUTICALS, INC. (US) 2011-04-21 — — US disclosed
WO-2011022508-A2 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VENTIRX PHARMACEUTICALS, INC. (US) 2011-02-24 — — WO disclosed
WO-2011022509-A2 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS VENTIRX PHARMACEUTICALS, INC. (US) 2011-02-24 — — WO disclosed
US-20100216989-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS, INC. (US) 2010-08-26 — — US disclosed
US-20100216989-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS, INC. (US) 2010-08-26 — — US disclosed
WO-2010054215-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES VENTIRX PHARMACEUTICALS, INC. (US) 2010-05-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100216989-A1 METHODS OF SYNTHESIS OF BENZAZEPINE DERIVATIVES MAOB, GABBR1, HNMT TLR8 4758/4885BCL2 655/4885BACE1 64/4885
US-20240299572-A1 NITROGEN-CONTAINING COMPOUND, CONJUGATE CONTAINING SAID COMPOUND, AND APPLICATION THEREOF TLR8, TLR9, TLR7 TLR8 1/4885BCL2 2122/4885BACE1 4603/4885
US-20110118235-A1 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS TLR8, TLR1, TLR7 TLR8 1/4885BCL2 322/4885BACE1 2119/4885
US-20110092485-A1 SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS TLR8, TLR1, TLR7 TLR8 1/4885BCL2 322/4885BACE1 2119/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.