Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.69 |
| ▸ | DGAT2 | Q96PD7 | 10/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17533778 | 0.90 | GRIN2B (0.75) | GRIN2BDGAT2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19408111 | 0.90 | GRIN2B (0.70) | GRIN2BDGAT2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17533777 | 0.89 | GRIN2B (0.69) | GRIN2BDGAT2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17513471 | 0.83 | GRIN2B (0.85) | GRIN2BCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17513473 | 0.83 | GRIN2B (0.85) | GRIN2BCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17533858 | 0.83 | GRIN2B (0.85) | GRIN2BCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17533806 | 0.82 | GRIN2B (0.82) | GRIN2BCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17513277 | 0.81 | GRIN2B (0.75) | GRIN2BCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17533798 | 0.81 | GRIN2B (0.80) | GRIN2BCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL17533854 | 0.80 | GRIN2B (0.70) | GRIN2BCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | AARS1, MTR, GARS1 | GRIN2B 1938/4885DGAT2 2308/4885CYP1A2 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.