Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16599076 | 0.84 | GPR183 (1.00) | GPR183 | |
| SCHEMBL16599072 | 0.84 | GPR183 (1.00) | GPR183 | |
| SCHEMBL19400203 | 0.84 | ALDH1A1 (0.69) | GPR183KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19400207 | 0.82 | ALDH1A1 (0.66) | GPR183KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL19400202 | 0.77 | MEN1 (0.73) | GPR183KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL16598975 | 0.77 | MAOB (0.68) | KDM4EALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL19400200 | 0.76 | ALDH1A1 (0.69) | GPR183KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3115705 | 0.74 | MAOB (1.00) | KDM4EALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL3115704 | 0.74 | MAOB (1.00) | KDM4EALDH1A1MEN1KMT2AMAOB | |
| SCHEMBL16598544 | 0.74 | GPR183 (1.00) | GPR183MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776979-B2 | EBI2 modulators | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-10-03 | — | — | US | claimed |