Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NT5E | P21589 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA6 | P23280 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL18584 | 1.00 | BLM (0.47) | BLMKDM4ENPSR1CYP2D6CYP2C19 | |
| Sulfuric Acid SCHEMBL3892286 | 1.00 | BLM (0.47) | BLMKDM4ENPSR1CYP2D6CYP2C19 | |
| SCHEMBL1230612 | 0.83 | — | — | |
| Sulfuric Acid SCHEMBL5581558 | 0.80 | BLM (0.62) | BLMKDM4ENPSR1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL9073672 | 0.79 | — | — | |
| Water SCHEMBL11792345 | 0.79 | NOS1 (0.37) | NOS1 | |
| Sulfuric Acid SCHEMBL10954704 | 0.71 | — | — | |
| Sulfuric Acid SCHEMBL27923396 | 0.69 | — | — | |
| Sulfuric Acid SCHEMBL526776 | 0.69 | — | — | |
| Sulfuric Acid SCHEMBL28217737 | 0.69 | KDM4E (0.53) | BLMKDM4ENPSR1CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017384-A1 | AZABENZIMIDAZOLE-BASED COMPOUNDS FOR MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION | ASTA Medica Aktiengesellschaft (DE) | 2000-07-12 | — | — | EP | claimed |
| WO-1999016438-A1 | AZABENZIMIDAZOLE-BASED COMPOUNDS FOR MODULATING SERINE/THREONINE PROTEIN KINASE FUNCTION | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1999-04-08 | — | — | WO | claimed |
| WO-2023138601-A1 | BRIDGED RING-SUBSTITUTED HETEROARYL-PYRAN DERIVATIVE, AND USE THEREOF | 南京明德新药研发有限公司 | 2023-07-27 | — | — | WO | disclosed |
| CN-115298174-A | Pyrimido-heterocyclic compounds and application thereof | 德昇济医药(无锡)有限公司 | 2022-11-04 | — | — | CN | disclosed |
| EP-2897961-A1 | DIHYDROPYRROLIDINO-PYRIMIDINES AS KINASE INHIBITORS | Novartis AG (CH) | 2015-07-29 | — | — | EP | disclosed |
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| EP-2882746-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Merck Patent GmbH (DE) | 2015-06-17 | — | — | EP | disclosed |
| CN-102083797-B | Tetrahydroisoquinolines, pharmaceutical compositions containing them and their use in therapy | ABBOTT GMBH & CO KG | 2014-06-04 | — | — | CN | disclosed |
| WO-2014047020-A1 | DIHYDROPYRROLIDINO-PYRIMIDINES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2014-03-27 | — | — | WO | disclosed |
| WO-2014023385-A1 | PYRIDOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-02-13 | — | — | WO | disclosed |
| CN-103224487-A | Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy | ABBOTT GMBH & CO KG | 2013-07-31 | — | — | CN | disclosed |
| EP-1144390-A2 | KINASE INHIBITORS | Amgen Inc., (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000043373-A2 | KINASE INHIBITORS | AMGEN INC. (US) | 2000-07-27 | — | — | WO | disclosed |
| US-5478946-A | Treating vascular system disorders or cartilage diseases | ABBOTT LABORATORIES (US) | 1995-12-26 | — | — | US | disclosed |
| EP-0296749-A1 | (Substituted aralkyl) heterocyclic compounds | ZENECA LIMITED (GB) | 1988-12-28 | — | — | EP | disclosed |
| US-4790912-A | ELECTROLYTICALLY-GENERATED HYDROGEN AND CATALYST CONVERT METAL SALT IN BATH TO METAL | TECHNO-INSTRUMENTS INVESTMENTS LTD. (IL) | 1988-12-13 | — | — | US | disclosed |
| US-4715894-A | AMINIMIZATION OF SMEAR | TECHNO INSTRUMENTS INVESTMENTS 1983 LTD. (IL) | 1987-12-29 | — | — | US | disclosed |
| US-4657632-A | CONTAINING A THIOUREA AND A UREA COMPOUND | TECHNO INSTRUMENTS INVESTMENTS 1983 LTD. (IL) | 1987-04-14 | — | — | US | disclosed |
| EP-0216531-A1 | Use of immersion tin and tin alloys as a bonding medium for multilayer circuits | TECHNO INSTRUMENTS INVESTMENTS 1983 LTD. (IL) | 1987-04-01 | — | — | EP | disclosed |
| US-3944560-A | BRONCHODILATOR | MERCK & CO., INC. (US) | 1976-03-16 | — | — | US | disclosed |