Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 9/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24259807 | 1.00 | ECE1 (0.44) | ECE1BACE1MAOAMAOBREN | |
| SCHEMBL5073478 | 0.94 | BACE1 (0.40) | ECE1BACE1MAOAMAOBREN | |
| SCHEMBL23332643 | 0.84 | MAOA (0.43) | BACE1MAOAMAOBMEN1GAA | |
| SCHEMBL7393270 | 0.84 | MEN1 (0.45) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL13884482 | 0.84 | MEN1 (0.45) | MEN1GAAKMT2ACTSSCTSK | |
| SCHEMBL30096350 | 0.83 | ECE1 (0.46) | ECE1BACE1RENAPPCTSS | |
| SCHEMBL19384891 | 0.82 | REN (0.49) | ECE1BACE1RENKMT2AAPP | |
| SCHEMBL20677180 | 0.82 | REN (0.49) | ECE1BACE1RENKMT2AAPP | |
| SCHEMBL20677179 | 0.82 | REN (0.49) | ECE1BACE1RENKMT2AAPP | |
| SCHEMBL29171095 | 0.82 | KMT2A (0.44) | MAOAMAOBMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162663-A1 | PRODRUGS OF CYTOTOXIC ACTIVE AGENTS HAVING ENZYMATICALLY CLEAVABLE GROUPS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | WO | disclosed |