Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11588966 | 0.93 | EPHX2 (0.67) | EPHX2POLBFAAHHPGDALDH1A1 | |
| SCHEMBL11590006 | 0.93 | EPHX2 (0.67) | EPHX2POLBFAAHHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL5766130 | 0.87 | CYP3A4 (0.54) | EPHX2POLBHPGDALOX12ALDH1A1 | |
| SCHEMBL6269552 | 0.84 | CNR1 (0.52) | EPHX2POLBHPGDALOX12ALDH1A1 | |
| SCHEMBL24539875 | 0.83 | TPSAB1 (0.51) | EPHX2POLBFAAHHPGDALDH1A1 | |
| SCHEMBL8260763 | 0.83 | CYP1A2 (0.50) | EPHX2POLBHPGDALDH1A1CNR1 | |
| SCHEMBL7092116 | 0.82 | KMT2A (0.57) | EPHX2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL18989620 | 0.81 | HPGD (0.55) | EPHX2POLBHPGDCYP2C19L3MBTL1 | |
| SCHEMBL3376541 | 0.80 | EPHX2 (0.58) | EPHX2POLBFAAHHPGDALOX12 | |
| Hydrochloric Acid SCHEMBL16372135 | 0.79 | ALOX12 (0.50) | EPHX2POLBHPGDALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017165640-A1 | 6-HYDROXY-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBOXAMIDES AS APJ AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-28 | — | — | WO | disclosed |