Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23352415 | 1.00 | MAPT (0.45) | MAPTKDM4ELMNACHRM2CHRM4 | |
| SCHEMBL26340003 | 0.84 | KDM4E (0.37) | KDM4EPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL26340042 | 0.81 | ALDH1A1 (0.42) | MAPTKDM4EPOLBALDH1A1RAB9A | |
| SCHEMBL7633022 | 0.73 | MEN1 (0.60) | MAPTKDM4ELMNACHRM2CHRM4 | |
| SCHEMBL18460807 | 0.71 | PTPN2 (0.70) | MAPTKDM4ELMNACHRM2CHRM4 | |
| SCHEMBL16398689 | 0.71 | POLB (0.61) | MAPTCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL25771258 | 0.70 | TP53 (0.39) | KDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL26340378 | 0.69 | ALDH1A1 (0.42) | MAPTKDM4ESMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL27400395 | 0.69 | PTPN2 (0.70) | MAPTKDM4ELMNACHRM2CHRM4 | |
| SCHEMBL16398974 | 0.69 | PTPN2 (0.51) | MAPTKDM4ECHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017165878-A1 | CRYSTAL FORMS AND METHODS OF SYNTHESIS OF (2R, 6R)-HYDROXYNORKETAMINE AND (2S, 6S)-HYDROXYNORKETAMINE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2017-09-28 | — | — | WO | disclosed |