Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAF1 | P21675 | 6/20 | 0.58 |
| ▸ | BRD1 | O95696 | 6/20 | 0.58 |
| ▸ | BRPF1 | P55201 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19405013 | 0.90 | TAF1 (0.61) | TAF1BRD1BRPF1ALDH1A1KDM4E | |
| SCHEMBL19404528 | 0.88 | BRD1 (0.71) | TAF1BRD1BRPF1LMNATP53 | |
| SCHEMBL19404424 | 0.85 | MEN1 (0.54) | TAF1BRD1BRPF1LMNAKMT2A | |
| SCHEMBL19404508 | 0.84 | BRD1 (0.77) | TAF1BRD1BRPF1LMNATP53 | |
| SCHEMBL19404427 | 0.82 | BRD1 (0.59) | TAF1BRD1BRPF1LMNAMAPK1 | |
| SCHEMBL19404591 | 0.82 | BRD1 (0.71) | TAF1BRD1BRPF1ALDH1A1KDM4E | |
| SCHEMBL19404848 | 0.82 | TAF1 (0.67) | TAF1BRD1BRPF1ALDH1A1KDM4E | |
| SCHEMBL19405004 | 0.82 | TAF1 (0.56) | TAF1BRD1BRPF1ALDH1A1KDM4E | |
| SCHEMBL19404590 | 0.80 | TAF1 (0.57) | TAF1BRD1BRPF1ALDH1A1KDM4E | |
| SCHEMBL19404495 | 0.78 | BRD1 (0.70) | TAF1BRD1BRPF1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017162661-A1 | 1H-BENZO[DE]ISOQUINOLINE-1,3(2H)-DIONES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-28 | — | — | WO | disclosed |