SCHEMBL1940751

SCHEMBL1940751

O=C(NC1CC1)C1=NC(c2ccncc2)CCC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX1 P07099 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.41
NAMPT P43490 4/20 0.39
ALDH1A1 P00352 3/20 0.38
GAA P10253 1/20 0.38
GFER P55789 1/20 0.38
MAPT P10636 1/20 0.38
CYP46A1 Q9Y6A2 1/20 0.37
SMYD3 Q9H7B4 1/20 0.36
GRM5 P41594 1/20 0.36
HTT P42858 1/20 0.36
MAOA P21397 1/20 0.35
MAOB P27338 1/20 0.35
MEN1 O00255 1/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
HPGD P15428 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1939017 0.81 NAPRT (0.41) EPHX1NAMPTALDH1A1GAAMAPT
SCHEMBL1544549 0.70 L3MBTL1 (0.61) L3MBTL1NAMPTALDH1A1GAAGFER
SCHEMBL18398412 0.67 NOS1 (0.64) ALDH1A1MAPTMEN1CYP1A2CYP3A4
SCHEMBL11623816 0.66 L3MBTL1 (0.74) EPHX1L3MBTL1NAMPTALDH1A1GAA
SCHEMBL23573440 0.65 CYP46A1 (0.56) L3MBTL1NAMPTALDH1A1GAAGFER
SCHEMBL23573442 0.65 CYP46A1 (0.56) L3MBTL1NAMPTALDH1A1GAAGFER
SCHEMBL12385843 0.64 GAA (0.55) L3MBTL1ALDH1A1GAAGFERCYP46A1
SCHEMBL17133511 0.64 GAA (0.55) L3MBTL1ALDH1A1GAAGFERCYP46A1
SCHEMBL21490121 0.64 SMYD3 (0.64) L3MBTL1ALDH1A1GAAGFERSMYD3
SCHEMBL19701280 0.64 SMYD3 (0.64) L3MBTL1ALDH1A1GAAGFERSMYD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331522-A2 TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF Purdue Pharma LP (US) 2011-06-15 EP claimed
EP-2331522-A2 TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF Purdue Pharma LP (US) 2011-06-15 EP disclosed
WO-2010014257-A2 TETRAHYDROPYRIDINYL AND DIHYDROPYRROLYL COMPOUNDS AND THE USE THEREOF PURDUE PHARMA L.P. (US) 2010-02-04 WO disclosed