Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364120 | 0.85 | ALDH1A1 (0.54) | GAAHSD17B10ALDH1A1LMNAKMT2A | |
| SCHEMBL19407720 | 0.84 | GAA (0.53) | GAAHSD17B10ALDH1A1LMNAKMT2A | |
| SCHEMBL1494233 | 0.78 | CNR1 (0.40) | GAAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL19364119 | 0.78 | GAA (0.64) | GAAHSD17B10ALDH1A1LMNAKMT2A | |
| SCHEMBL2484392 | 0.77 | GFER (0.45) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL18331907 | 0.74 | ALDH1A1 (0.54) | GAAHSD17B10ALDH1A1LMNAKMT2A | |
| SCHEMBL10003032 | 0.74 | FFAR4 (0.48) | GAAALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL13848365 | 0.74 | ALDH1A1 (0.61) | GAAHSD17B10ALDH1A1LMNAKMT2A | |
| SCHEMBL8752466 | 0.74 | ALDH1A1 (0.70) | ALDH1A1LMNAKMT2AMEN1FFAR4 | |
| SCHEMBL28597349 | 0.72 | FFAR4 (0.66) | GAAALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017165255-A1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC. (US) | 2017-09-28 | — | — | WO | disclosed |