Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.46 |
| ▸ | CES2 | O00748 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28419426 | 0.93 | CES2 (0.48) | CES1CES2ALDH1A1TP53MEN1 | |
| SCHEMBL11296708 | 0.91 | CES2 (0.50) | CES1CES2ALDH1A1TP53MEN1 | |
| SCHEMBL11025699 | 0.91 | CES2 (0.50) | CES1CES2ALDH1A1TP53MEN1 | |
| SCHEMBL11288198 | 0.91 | CES2 (0.50) | CES1CES2ALDH1A1TP53MEN1 | |
| Hydrochloric Acid SCHEMBL28349226 | 0.91 | CES2 (0.46) | CES1CES2ALDH1A1TP53MEN1 | |
| SCHEMBL11294421 | 0.91 | CES2 (0.50) | CES1CES2ALDH1A1TP53MEN1 | |
| SCHEMBL10734667 | 0.85 | — | — | |
| SCHEMBL21351040 | 0.81 | FAAH (0.68) | LMNATP53MEN1KMT2AFAAH | |
| SCHEMBL19661878 | 0.81 | FAAH (0.62) | LMNATP53MEN1KMT2AFAAH | |
| SCHEMBL15474220 | 0.78 | CES1 (0.48) | CES1CES2ALDH1A1TP53CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10744179-B2 | Method for treatment of inflammatory skin disorders with inhibitors of IL-36 proteolytic processing | The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy (IE) | 2020-08-18 | — | — | US | disclosed |
| US-20170281716-A1 | USE OF INHIBITORS OF IL-36 PROTEOLYTIC PROCESSING FOR THE TREATMENT AND/OR REDUCTION OF INFLAMMATION | The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy (IE) | 2017-10-05 | — | — | US | disclosed |
| CN-1107836-A | Novel substituted guanidine derivatives, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-09-06 | — | — | CN | disclosed |
| CN-1028592-C | Insecticidal composition containing novel substituted guanidine derivative and application | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-05-31 | — | — | CN | disclosed |
| CN-1059719-A | Novel substituted guanidine derivatives, their preparation and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1992-03-25 | — | — | CN | disclosed |