Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 5/20 | 0.40 |
| ▸ | PPARG | P37231 | 4/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.36 |
| ▸ | TUBB | P07437 | 3/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19410286 | 1.00 | CYP3A4 (0.44) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL19410290 | 1.00 | CYP3A4 (0.44) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL19410294 | 1.00 | CYP3A4 (0.44) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL16993477 | 1.00 | CYP3A4 (0.44) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL19421024 | 0.95 | CYP3A4 (0.40) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL19421021 | 0.95 | CYP3A4 (0.40) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL19421023 | 0.95 | CYP3A4 (0.40) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL19421025 | 0.95 | CYP3A4 (0.40) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL19421022 | 0.95 | CYP3A4 (0.40) | CYP3A4PTGS1PPARDPPARGPTPN1 | |
| SCHEMBL18241815 | 0.92 | TUBB4A (0.45) | CYP3A4PTGS1PPARDPPARGPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170281588-A1 | Compositions and Methods for Treating Epithelial Cancer | YALE UNIVERSITY | 2017-10-05 | — | — | US | claimed |
| US-10265294-B2 | Compositions and methods for treating epithelial cancer | YALE UNIVERSITY (US) | 2019-04-23 | — | — | US | disclosed |
| US-10265294-B2 | Compositions and methods for treating epithelial cancer | YALE UNIVERSITY (US) | 2019-04-23 | — | — | US | disclosed |
| US-20170281588-A1 | Compositions and Methods for Treating Epithelial Cancer | YALE UNIVERSITY | 2017-10-05 | — | — | US | disclosed |
| US-20170281588-A1 | Compositions and Methods for Treating Epithelial Cancer | YALE UNIVERSITY | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170281588-A1 | Compositions and Methods for Treating Epithelial Cancer | PKD1, SLC16A1, FOLR1 | CYP3A4 4066/4885PTGS1 2825/4885PPARD 706/4885 |
| US-10265294-B2 | Compositions and methods for treating epithelial cancer | PKD1, SLC16A1, FOLR1 | CYP3A4 4066/4885PTGS1 2825/4885PPARD 706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.