Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21140886 | 0.81 | JAK2 (0.35) | JAK2JAK1TYK2 | |
| SCHEMBL9915284 | 0.79 | KDM4E (0.31) | — | |
| SCHEMBL12697499 | 0.70 | — | — | |
| SCHEMBL24758647 | 0.68 | — | — | |
| SCHEMBL27947164 | 0.66 | — | — | |
| SCHEMBL32677379 | 0.65 | EGFR (0.37) | EGFR | |
| SCHEMBL29071990 | 0.65 | EGFR (0.37) | EGFR | |
| SCHEMBL23507843 | 0.65 | CYP3A4 (0.42) | EGFR | |
| SCHEMBL23079428 | 0.64 | LMNA (0.33) | — | |
| SCHEMBL20362662 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9777035-B2 | 4′-substituted nucleoside reverse transcriptase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-10-03 | — | — | US | disclosed |