Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.44 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | NEK7 | Q8TDX7 | 7/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | HCK | P08631 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.41 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13829837 | 0.88 | FLT3 (0.44) | FLT3LIMK1ROCK2KDRKIT | |
| SCHEMBL13829654 | 0.82 | LRRK2 (0.44) | PIK3CAMTORPIK3CGSTK3 | |
| SCHEMBL13828400 | 0.81 | RIPK1 (0.62) | KDRRIPK1ABL1SRCPIK3CD | |
| SCHEMBL20793723 | 0.79 | FAAH (0.40) | FLT3ROCK2KDRKITROCK1 | |
| SCHEMBL9010 | 0.77 | PIK3CG (0.54) | KDRRIPK1ABL1SRCPIK3CD | |
| SCHEMBL13717800 | 0.76 | CSNK1E (0.45) | KDRABL1SRCPIK3CDEGFR | |
| SCHEMBL24096531 | 0.75 | NEK7 (0.65) | FLT3NEK7 | |
| SCHEMBL30320596 | 0.75 | NEK7 (0.65) | FLT3NEK7 | |
| SCHEMBL11928101 | 0.74 | PIK3CD (0.56) | KDRABL1SRCPIK3CDEGFR | |
| SCHEMBL24096483 | 0.74 | NEK7 (0.66) | FLT3NEK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9775841-B2 | Compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2017-10-03 | — | — | US | disclosed |