SCHEMBL19417974

SCHEMBL19417974

CC1CC/C=C/C(=N)Cc2c(Cl)c(O)cc(O)c2C(=O)OCCC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 4/20 0.48
MAPT P10636 3/20 0.40
HSP90AA1 P07900 2/20 0.40
RAB9A P51151 2/20 0.40
NPSR1 Q6W5P4 2/20 0.40
ACLY P53396 2/20 0.40
GAA P10253 1/20 0.40
NLRP3 Q96P20 1/20 0.40
CBR1 P16152 1/20 0.40
PTGS2 P35354 1/20 0.40
FTO Q9C0B1 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 1/20 0.40
STAT6 P42226 8/20 0.38
SMAD3 P84022 8/20 0.38
SMAD2 Q15796 8/20 0.38
GEMIN4 P57678 1/20 0.36
HSF1 Q00613 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20840851 0.85 HSP90AB1 (0.50) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL10186746 0.82 HSP90AB1 (0.52) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL19418327 0.82 HSP90AB1 (0.52) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL20840840 0.82 HSP90AB1 (0.46) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL20840838 0.80 HSP90AB1 (0.48) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL18871691 0.78 HSP90AB1 (0.44) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL20840837 0.76 HSP90AB1 (0.42) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL19418380 0.75 HSP90AB1 (0.44) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL20840841 0.75 HSP90AB1 (0.49) HSP90AB1MAPTHSP90AA1RAB9ANPSR1
SCHEMBL19418239 0.72 HSP90AB1 (0.41) HSP90AB1HSP90AA1ACLYSTAT6SMAD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2136799-B1 MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90 UNIV STRASBOURG (FR) 2017-10-04 EP disclosed