Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.36 |
| ▸ | ACLY | P53396 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | CBR1 | P16152 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | STAT6 | P42226 | 8/20 | 0.33 |
| ▸ | SMAD3 | P84022 | 8/20 | 0.33 |
| ▸ | SMAD2 | Q15796 | 8/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19418327 | 0.93 | HSP90AB1 (0.52) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL10186746 | 0.93 | HSP90AB1 (0.52) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL20840840 | 0.85 | HSP90AB1 (0.46) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL19417974 | 0.85 | HSP90AB1 (0.48) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL19418380 | 0.83 | HSP90AB1 (0.44) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL19418239 | 0.82 | HSP90AB1 (0.41) | HSP90AB1HSP90AA1ACLYSTAT6SMAD3 | |
| SCHEMBL18871691 | 0.81 | HSP90AB1 (0.44) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL20840837 | 0.81 | HSP90AB1 (0.42) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL10150174 | 0.81 | HSP90AB1 (0.66) | HSP90AB1HSP90AA1ACLYMAPTGAA | |
| SCHEMBL20840852 | 0.79 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1ACLYMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239856-B2 | Synthesis of resorcylic acid lactones useful as therapeutic agents | UNIVERSITY DE STRASBOURG (FR) | 2019-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10239856-B2 | Synthesis of resorcylic acid lactones useful as therapeutic agents | HSP90AA1, HSP90AB1, HSP90AB2P | HSP90AB1 2/4885HSP90AA1 1/4885ACLY 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.