Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8064319 | 0.86 | MAPK1 (0.50) | KMT2AMAPK1KDM4EL3MBTL1TSHR | |
| SCHEMBL23341275 | 0.84 | PIP5K1C (0.40) | MAPK1KDM4ETSHR | |
| SCHEMBL17082346 | 0.83 | PIK3CD (0.39) | MAPK1KDM4EL3MBTL1 | |
| SCHEMBL11960799 | 0.81 | PARP1 (0.37) | — | |
| SCHEMBL16315245 | 0.80 | ALDH1A1 (0.37) | MAPK1OPRD1L3MBTL1TSHR | |
| SCHEMBL8065893 | 0.79 | KDM4E (0.37) | NNMTKDM4E | |
| SCHEMBL7876853 | 0.77 | KMT2A (0.37) | KMT2A | |
| SCHEMBL22084822 | 0.77 | — | — | |
| SCHEMBL14978738 | 0.76 | PTK2 (0.48) | KMT2AKDM4EL3MBTL1 | |
| SCHEMBL12459107 | 0.75 | NNMT (0.38) | KMT2ANNMTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925757-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |