Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.40 |
| ▸ | GPR39 | O43194 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21920755 | 0.79 | CRHR1 (0.48) | CRHR1PDE10AKDM4ETSHRHSD17B10 | |
| SCHEMBL17141620 | 0.79 | NPC1 (0.48) | PDE10AKDM4ETSHRHSD17B10GPR39 | |
| SCHEMBL13685171 | 0.79 | PDE10A (0.41) | CRHR1ABL1PDE10AKDM4ETSHR | |
| SCHEMBL1108661 | 0.79 | CRHR1 (0.51) | CRHR1ABL1PDE10AKDM4ETSHR | |
| SCHEMBL4037459 | 0.79 | PDE10A (0.41) | CRHR1ABL1PDE10AKDM4ETSHR | |
| SCHEMBL17141822 | 0.79 | PDE10A (0.44) | CRHR1PDE10AKDM4ETSHRHSD17B10 | |
| SCHEMBL16030699 | 0.77 | USP30 (0.42) | CRHR1KDM4ETSHRHSD17B10CYP2D6 | |
| SCHEMBL16030698 | 0.77 | USP30 (0.42) | CRHR1KDM4ETSHRHSD17B10CYP2D6 | |
| SCHEMBL30775294 | 0.76 | KCNH2 (0.48) | ABL1FLT3TYRO3MERTKGAS6 | |
| SCHEMBL4033485 | 0.75 | GPR39 (0.40) | CRHR1ABL1PDE10AKDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925757-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES | NOVARTIS AG (CH) | 2017-10-04 | — | — | EP | disclosed |