Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | PDE5A | O76074 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18136184 | 0.86 | LMNA (0.39) | L3MBTL1NPC1KDM4EPDE4AKDM1A | |
| SCHEMBL28002301 | 0.85 | KDM1A (0.41) | L3MBTL1NPC1KDM4EHCAR2PDE4A | |
| SCHEMBL18135204 | 0.79 | KDM1A (0.37) | L3MBTL1NPC1KDM4EHCAR2PDE4A | |
| SCHEMBL22912511 | 0.78 | NPC1 (0.40) | L3MBTL1NPC1KDM4EPDE4AKDM1A | |
| SCHEMBL20970404 | 0.78 | L3MBTL1 (0.47) | L3MBTL1NPC1KDM4EPDE4APDE5A | |
| SCHEMBL18133870 | 0.78 | HDAC1 (0.37) | L3MBTL1NPC1PDE4AKDM1AMAOA | |
| SCHEMBL10116180 | 0.76 | KDM1A (0.43) | L3MBTL1NPC1KDM4EPDE4APDE4B | |
| SCHEMBL31366303 | 0.75 | — | — | |
| SCHEMBL8371342 | 0.75 | — | — | |
| SCHEMBL4386016 | 0.74 | IDO1 (0.48) | L3MBTL1NPC1KDM4EPDE4AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017172979-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS AND METHODS OF USE | ARAXES PHARMA LLC (US) | 2017-10-05 | — | — | WO | disclosed |