Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Stearyl Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.69 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NAAA | Q02083 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11806763 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL8846576 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL11798415 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL8846570 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL11806705 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL11805402 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Stearyl Fumaric Acid SCHEMBL194237 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| Stearyl Fumaric Acid SCHEMBL11590339 | 1.00 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL9679071 | 0.96 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 | |
| SCHEMBL8846775 | 0.96 | HCAR2 (0.69) | HCAR2ATMMAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116509844-B | Pharmaceutical composition of dipeptidyl peptidase 4 inhibitor and preparation method and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2024-06-04 | — | — | CN | claimed |
| US-20240115575-A1 | PHARMACEUTICAL COMPOSITION OF MULTI-TARGET PROTEIN KINASE INHIBITORS, AND USE THEREOF | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD (CN) | 2024-04-11 | — | — | US | claimed |
| CN-117427143-A | Pharmaceutical composition containing peptidomimetic compounds and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2024-01-23 | — | — | CN | claimed |
| EP-4272741-A1 | PHARMACEUTICAL COMPOSITION OF MULTI-TARGET PROTEIN KINASE INHIBITORS, AND USE THEREOF | CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. (CN) | 2023-11-08 | — | — | EP | claimed |
| WO-2023186031-A1 | PHARMACEUTICAL COMPOSITION OF MULTI-TARGET PROTEIN KINASE INHIBITOR, USE THEREOF, AND METHOD FOR PREPARING SAME | 石药集团中奇制药技术（石家庄）有限公司 | 2023-10-05 | — | — | WO | claimed |
| CN-114699378-B | Sitagliptin phosphate pharmaceutical preparation and preparation method thereof | 北京福元医药股份有限公司 | 2023-09-26 | — | — | CN | claimed |
| CN-116327769-A | Pharmaceutical composition containing sitagliptin phosphate and metformin hydrochloride and preparation method thereof | 重庆圣华曦药业股份有限公司 | 2023-06-27 | — | — | CN | claimed |
| CN-114641277-B | Pharmaceutical composition of dipeptidyl peptidase 4 inhibitor and preparation method and application thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2023-06-13 | — | — | CN | claimed |
| CN-114699378-A | Sitagliptin phosphate pharmaceutical preparation and preparation method thereof | 北京福元医药股份有限公司 | 2022-07-05 | — | — | CN | claimed |
| WO-2021136507-A1 | PHARMACEUTICAL COMPOSITION OF DIPEPTIDYL PEPTIDASE-4 INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 石药集团中奇制药技术（石家庄）有限公司 | 2021-07-08 | — | — | WO | claimed |
| US-9717707-B2 | Pharmaceutical statin composition | HEXAL AG (DE) | 2017-08-01 | — | — | US | claimed |
| US-20170065531-A9 | ALCOHOL-RESISTANT ORAL PHARMACEUTICAL FORM | ETHYPHARM SA (FR) | 2017-03-09 | — | — | US | claimed |
| EP-2787987-B1 | NEW PHARMACEUTICAL STATIN COMPOSITIONS | HEXAL AG (DE) | 2016-06-01 | — | — | EP | claimed |
| US-20150250737-A1 | ALCOHOL-RESISTANT ORAL PHARMACEUTICAL FORM | ETHYPHARM SA (FR) | 2015-09-10 | — | — | US | claimed |
| CN-103169680-B | Diclofenac sodium sustained-release tablet and method for preparing same | SHENZHEN GUOYUAN PHARMACEUTICAL CO LTD | 2015-05-06 | — | — | CN | claimed |
| US-20140328936-A1 | NOVEL PHARMACEUTICAL STATIN COMPOSITION | HEXAL AG (DE) | 2014-11-06 | — | — | US | claimed |
| CN-103169680-A | Diclofenac sodium sustained-release tablet and method for preparing same | SHENZHEN GUOYUAN PHARMACEUTICAL CO LTD | 2013-06-26 | — | — | CN | claimed |
| US-20130059010-A1 | ALCOHOL-RESISTANT ORAL PHARMACEUTICAL FORM | ETHYPHARM (FR) | 2013-03-07 | — | — | US | claimed |
| CN-101732267-B | Pravastatin sodium tablet, application and preparation method thereof | LIVZON PHARMACEUTICAL GROUP | 2012-05-30 | — | — | CN | claimed |
| CN-101732267-A | Pravastatin sodium tablet as well as application and preparation method thereof | LIVZON PHARMACEUTICAL GROUP IN | 2010-06-16 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240115575-A1 | PHARMACEUTICAL COMPOSITION OF MULTI-TARGET PROTEIN KINASE INHIBITORS, AND USE THEREOF | DMPK, PRKCB, PRKCA | HCAR2 3631/4885ATM 504/4885MAPT 1754/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.