Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102983 | 0.81 | P2RX4 (0.44) | — | |
| SCHEMBL9893075 | 0.80 | EPHX2 (0.67) | EPHX2EPHX1 | |
| SCHEMBL13102986 | 0.80 | KDM4E (0.53) | — | |
| SCHEMBL6539120 | 0.79 | EPHX2 (0.65) | EPHX2EPHX1 | |
| SCHEMBL13306160 | 0.77 | EPHX2 (0.62) | EPHX2EPHX1 | |
| SCHEMBL24865940 | 0.76 | RECQL (0.55) | EPHX2EPHX1 | |
| SCHEMBL4118663 | 0.76 | EPHX2 (0.96) | EPHX2EPHX1 | |
| SCHEMBL9891911 | 0.76 | EPHX2 (0.61) | EPHX2EPHX1 | |
| SCHEMBL23041884 | 0.76 | EPHX2 (0.61) | EPHX2EPHX1 | |
| SCHEMBL3317488 | 0.76 | EPHX2 (0.61) | EPHX2EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10647708-B2 | Tetrahydroisoquinoline derived PRMT5-inhibitors | CTXT PTY. LTD (AU) | 2020-05-12 | — | — | US | disclosed |
| US-20170283407-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | CTXT PTY. LTD. (AU) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647708-B2 | Tetrahydroisoquinoline derived PRMT5-inhibitors | PRMT5, PRMT3, PRMT1 | EPHX2 1571/4885EPHX1 1822/4885 |
| US-20170283407-A1 | TETRAHYDROISOQUINOLINE DERIVED PRMT5-INHIBITORS | PRMT5, PRMT3, PRMT1 | EPHX2 1571/4885EPHX1 1822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.