Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19429624 | 0.82 | KDM4E (0.43) | SMN1; SMN2BRD4ALDH1A1ATMKDM4E | |
| SCHEMBL29626163 | 0.79 | KDM4E (0.42) | SMN1; SMN2ALDH1A1ATMKDM4ELMNA | |
| SCHEMBL19377597 | 0.79 | KDM4E (0.42) | SMN1; SMN2ALDH1A1ATMKDM4ELMNA | |
| SCHEMBL19429656 | 0.78 | SMN1; SMN2 (0.38) | NPC1SMN1; SMN2TSHRTP53BRD4 | |
| SCHEMBL23370712 | 0.78 | FEN1 (0.39) | NPC1SMN1; SMN2TSHRTP53BRD4 | |
| SCHEMBL29626177 | 0.78 | GRIA1 (0.50) | SMN1; SMN2TSHRALDH1A1ATMMAPT | |
| SCHEMBL19377934 | 0.78 | GRIA1 (0.50) | SMN1; SMN2TSHRALDH1A1ATMMAPT | |
| SCHEMBL19429626 | 0.78 | FEN1 (0.39) | NPC1SMN1; SMN2TSHRTP53BRD4 | |
| SCHEMBL28681776 | 0.78 | ALDH1A1 (0.43) | NPC1SMN1; SMN2TSHRTP53ALDH1A1 | |
| SCHEMBL19403731 | 0.77 | KDM4E (0.40) | SMN1; SMN2TP53BRD4ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| WO-2017172596-A1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORPORATION (US) | 2017-10-05 | — | — | WO | disclosed |