Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19430406 | 0.95 | GBA1 (0.46) | HPGDSMN1; SMN2GBA1KDM4ENPSR1 | |
| SCHEMBL19421551 | 0.91 | HPGD (0.47) | HPGDSMN1; SMN2GBA1KDM4ENPSR1 | |
| SCHEMBL19429863 | 0.90 | GBA1 (0.49) | GBA1KDM4EKDM5BPRMT6 | |
| SCHEMBL19430234 | 0.89 | GBA1 (0.48) | GBA1KDM5BPRMT6 | |
| SCHEMBL19429971 | 0.85 | GBA1 (0.44) | GBA1KDM4EKDM5BKMT2APRMT6 | |
| SCHEMBL19430008 | 0.83 | KDM5B (0.44) | GBA1KDM4ENPSR1HTTALDH1A1 | |
| SCHEMBL19430272 | 0.83 | KDM5B (0.48) | KDM5BPRMT6 | |
| SCHEMBL19429860 | 0.82 | SMN1; SMN2 (0.44) | HPGDSMN1; SMN2KDM4ENPSR1HTT | |
| SCHEMBL19430024 | 0.82 | PRMT6 (0.43) | HPGDSMN1; SMN2GBA1KDM4EALDH1A1 | |
| SCHEMBL19430387 | 0.81 | KDM5B (0.42) | GBA1KDM5BPRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170280720-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170280720-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | HPGD 828/4885SMN1; SMN2 1252/4885GBA1 2736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.