Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 13/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | USP2 | O75604 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247470 | 0.90 | MAPT (0.89) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2245512 | 0.90 | MAPT (0.82) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2247199 | 0.90 | MAPT (0.86) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2244745 | 0.86 | MAPT (0.87) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2243823 | 0.86 | MAPT (0.77) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2245527 | 0.86 | TP53 (1.00) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2240507 | 0.86 | MAPT (0.87) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2245519 | 0.85 | ALDH1A1 (1.00) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2242829 | 0.84 | MAPT (0.78) | TP53MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL19428467 | 0.84 | MAPT (0.74) | TP53MAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170283436-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | EVOTEC (UK) LTD. (GB) | 2017-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170283436-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, FABP7 | TP53 743/4885MAPT 7/4885ALDH1A1 3949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.