Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.44 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28383972 | 0.81 | KDM4E (0.35) | SYKKDM4EMAPTMAPKAPK2HSD11B1 | |
| SCHEMBL17899867 | 0.80 | SLC22A12 (0.46) | KDM4EHSD11B1 | |
| SCHEMBL19435524 | 0.79 | IL1B (0.45) | ERN1KDM4EMAPTMAPKAPK2HSD11B1 | |
| SCHEMBL23129259 | 0.78 | SLC22A12 (0.38) | SYKKDM4EMAPTMAPKAPK2HSD11B1 | |
| SCHEMBL19435459 | 0.76 | ELANE (0.41) | — | |
| SCHEMBL19562917 | 0.75 | SLC22A12 (0.51) | KDM4EMAPTMAPKAPK2HSD11B1MAP4K4 | |
| SCHEMBL2140701 | 0.74 | SLC22A12 (0.48) | SYKKDM4EFYNPRKDC | |
| SCHEMBL19435567 | 0.73 | SLC22A12 (0.54) | GAKRIPK2COQ8ANLKKIT | |
| SCHEMBL19435548 | 0.73 | NOTUM (0.38) | GAKRIPK2COQ8ANLKKIT | |
| SCHEMBL20554047 | 0.73 | SYK (0.57) | GAKRIPK2COQ8ANLKSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241822-B1 | URAT1 INHIBITOR | NIPPON CHEMIPHAR CO (JP) | 2021-03-24 | — | — | EP | disclosed |
| CN-107108478-B | URAT1 inhibitors | 日本化学药品株式会社 | 2020-04-24 | — | — | CN | disclosed |
| US-10173990-B2 | URAT1 inhibitor | NIPPON CHEMIPHAR CO., LTD. (JP) | 2019-01-08 | — | — | US | disclosed |
| EP-3241822-A1 | URAT1 INHIBITOR | Nippon Chemiphar Co., Ltd. (JP) | 2017-11-08 | — | — | EP | disclosed |
| US-20170290795-A1 | URAT1 INHIBITOR | J-PHARMA CO., LTD. (JP) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170290795-A1 | URAT1 INHIBITOR | SLC10A1, XDH, URB2 | GAK 3364/4885RIPK2 2736/4885COQ8A 754/4885 |
| US-10173990-B2 | URAT1 inhibitor | SLC10A1, XDH, URB2 | GAK 3345/4885RIPK2 2754/4885COQ8A 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.