Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19966681 | 0.93 | HRH3 (0.43) | LMNAMAPTHRH3SMN1; SMN2HSD17B10 | |
| SCHEMBL8261413 | 0.82 | LMNA (0.52) | LMNAMAPTHRH3SMN1; SMN2HSD17B10 | |
| SCHEMBL18893549 | 0.80 | KDM4E (0.59) | MAPTHRH3SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL11955036 | 0.79 | CYP2D6 (0.49) | SMN1; SMN2HSD17B10ALDH1A1KMT2AMEN1 | |
| SCHEMBL23251555 | 0.77 | HDAC3 (0.42) | LMNAHRH3SMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL6663539 | 0.77 | — | — | |
| SCHEMBL10498542 | 0.77 | LMNA (0.70) | LMNAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14192112 | 0.76 | LMNA (0.46) | LMNAMAPTHRH3SMN1; SMN2HSD17B10 | |
| SCHEMBL2633644 | 0.75 | MEN1 (0.54) | LMNAMAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL21121000 | 0.74 | HRH3 (0.38) | HRH3ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783525-B2 | Map kinase modulators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-10-10 | — | — | US | disclosed |