Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 11/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.97 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meperidine SCHEMBL1083668 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL2860723 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL41046 | 1.00 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL25431 | 0.99 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL28905219 | 0.97 | OPRM1 (0.97) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL27945061 | 0.97 | OPRM1 (0.97) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL28695347 | 0.96 | OPRM1 (0.94) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL3054250 | 0.96 | OPRM1 (0.94) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Ethoheptazine SCHEMBL24581 | 0.93 | OPRM1 (0.90) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL12574647 | 0.89 | OPRM1 (0.82) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9427435-B2 | Narcotic emulsion formulations for treatment of cancer pain | TEIKOKU PHARMA USA, INC. (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150141461-A1 | Narcotic Emulsion Formulations for Treatment of Cancer Pain | TEIKOKU PHARMA USA, INC. | 2015-05-21 | — | — | US | disclosed |
| US-8871791-B2 | Narcotic emulsion formulations for treatment of cancer pain | TEIKOKU PHARMA USA, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| EP-2400838-A1 | NARCOTIC EMULSION FORMULATIONS FOR TREATMENT OF CANCER PAIN | Teikoku Pharma USA, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010098897-A1 | NARCOTIC EMULSION FORMULATIONS FOR TREATMENT OF CANCER PAIN | TEIKOKU PHARMA USA, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| US-20100216842-A1 | Narcotic Emulsion Formulations for Treatment of Cancer Pain | TEIKOKU PHARMA USA INC. | 2010-08-26 | — | — | US | disclosed |
| US-7674482-B2 | for producing acetylcholine and serotonin; improved cognitive function, induced and maintained sleep, reduced pain, inflammation, blood pressure, anxiety, asthma, duration of viral infection, insulin resistance, appetite, and treating depression | TARGETED MEDICAL PHARMA INC. (US) | 2010-03-09 | — | — | US | disclosed |
| EP-1996213-A2 | METHOD AND COMPOSITIONS FOR POTENTIATING PHARMACEUTICALS WITH AMINO ACID BASED MEDICAL FOODS | Shell, William E. (US) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007111958-A2 | METHOD AND COMPOSITIONS FOR POTENTIATING PHARMACEUTICALS WITH AMINO ACID BASED MEDICAL FOODS | SHELL WILLIAM E (US) | 2007-10-04 | — | — | WO | disclosed |
| US-20060159726-A1 | for producing acetylcholine and serotonin; improved cognitive function, induced and maintained sleep, reduced pain, inflammation, blood pressure, anxiety, asthma, duration of viral infection, insulin resistance, appetite, and treating depression | TARGETED MEDICAL PHARMA, INC. | 2006-07-20 | — | — | US | disclosed |