Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meperidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 10/20 | 0.94 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.94 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.94 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.94 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meperidine SCHEMBL25431 | 0.97 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL28905219 | 0.96 | OPRM1 (0.97) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL41046 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL27945061 | 0.96 | OPRM1 (0.97) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL2860723 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL1083668 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL194412 | 0.96 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL28695347 | 0.94 | OPRM1 (0.94) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Ethoheptazine SCHEMBL24581 | 0.92 | OPRM1 (0.90) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| Meperidine SCHEMBL12574647 | 0.88 | OPRM1 (0.82) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101896161-A | Solid formulations of crystalline compounds | PURDUE RESEARCH FOUNDATION | 2010-11-24 | — | — | CN | disclosed |
| US-20100222311-A1 | SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS | PURDUE RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
| EP-2021502-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | Oy Jurilab Ltd (FI) | 2009-02-11 | — | — | EP | disclosed |
| CN-100438873-C | Application of tetrodotoxin as analgesic tolerance inhibitor in preparation of compound pain relieving preparation | ZHIQIANG HUANG (CN) | 2008-12-03 | — | — | CN | disclosed |
| WO-2007128884-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | OY JURILAB LTD (FI) | 2007-11-15 | — | — | WO | disclosed |
| CN-101031298-A | Medicine with analgesic effect | WANG JIANSHENG (CN) | 2007-09-05 | — | — | CN | disclosed |
| CN-1968694-A | An analgesic pharmaceutical composition | WANG JIANSHENG (CN) | 2007-05-23 | — | — | CN | disclosed |
| CN-1864685-A | Application of tetrodotoxin as analgesic tolerance inhibitor in preparation of compound pain relieving preparation | HUANG ZHIQIANG (CN) | 2006-11-22 | — | — | CN | disclosed |
| CN-1194693-C | Application of paralytic PSP toxin in preparing antalgesic medicine | INST OCEANOLOGY CHINESE ACADEM (CN) | 2005-03-30 | — | — | CN | disclosed |
| CN-1485036-A | Compound demerol formulation | 广州贝氏药业有限公司 | 2004-03-31 | — | — | CN | disclosed |
| CN-1468597-A | Continuous released medical composition | F.H.福尔丁有限公司 | 2004-01-21 | — | — | CN | disclosed |