Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15655811 | 0.80 | ADORA3 (0.47) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL22815484 | 0.69 | IDO1 (0.45) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL12826807 | 0.64 | CA12 (0.56) | SMN1; SMN2NPSR1MEN1NPC1RAB9A | |
| SCHEMBL13715618 | 0.63 | PIM1 (0.49) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL22327927 | 0.63 | MAPT (0.47) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL8889925 | 0.63 | MAP2K4 (0.45) | SMN1; SMN2NPC1RAB9AMAPK1HTR7 | |
| SCHEMBL2860957 | 0.62 | AURKA (0.66) | NPC1RAB9ALMNATP53MAPK1 | |
| SCHEMBL10875241 | 0.62 | HSP90AA1 (0.54) | LMNAHTR7HSP90AA1GSK3AGSK3B | |
| SCHEMBL8888803 | 0.62 | MAPK13 (0.48) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL15661915 | 0.62 | MAPK13 (0.48) | MAPTALOX15SMN1; SMN2NFKB1NFKB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783545-B2 | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome | USHER III INITIATIVE, INC. (US) | 2017-10-10 | — | — | US | disclosed |