Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11980690 | 0.88 | TDP1 (0.46) | S1PR1TDP1LMNACASP6S1PR3 | |
| SCHEMBL27859789 | 0.81 | HPGD (0.56) | TDP1LMNAKMT2AMEN1POLB | |
| SCHEMBL991715 | 0.79 | TDP1 (0.49) | S1PR1TDP1LMNACASP6KMT2A | |
| SCHEMBL19442078 | 0.73 | KMT2A (0.62) | S1PR1TDP1LMNACASP6KMT2A | |
| SCHEMBL15268184 | 0.71 | CHRNB2 (0.46) | LMNAKMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL19497285 | 0.69 | S1PR3 (0.45) | S1PR1S1PR3TSHRTRPM8 | |
| SCHEMBL19442032 | 0.69 | CA12 (0.37) | TDP1LMNAKMT2AMEN1POLB | |
| SCHEMBL11985248 | 0.68 | RAB9A (0.46) | LMNAPOLBHPGDALDH1A1 | |
| SCHEMBL19442077 | 0.68 | CYP1A2 (0.41) | LMNAKMT2AMEN1NPSR1TSHR | |
| SCHEMBL8737680 | 0.67 | HCAR2 (0.44) | LMNAKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782382-B2 | TOFA analogs useful in treating dermatological disorders or conditions | DERMIRA (CANADA), INC. (US) | 2017-10-10 | — | — | US | disclosed |