Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 10/20 | 0.53 |
| ▸ | ACE | P12821 | 4/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11980699 | 0.90 | FKBP1A (0.53) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL16650233 | 0.83 | FKBP1A (0.46) | FKBP1AACEKLK7KLK5 | |
| SCHEMBL11985167 | 0.81 | FKBP1A (0.51) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6787731 | 0.81 | FKBP1A (0.62) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6787737 | 0.81 | FKBP1A (0.62) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6786158 | 0.81 | FKBP1A (0.65) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6786152 | 0.81 | FKBP1A (0.65) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL7969235 | 0.81 | FKBP1A (0.65) | FKBP1AACEKLK7KLK5PREP | |
| SCHEMBL6783140 | 0.80 | FKBP1A (0.58) | FKBP1AACEKLK7KLK5 | |
| SCHEMBL6787199 | 0.80 | FKBP1A (0.58) | FKBP1AACEKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782382-B2 | TOFA analogs useful in treating dermatological disorders or conditions | DERMIRA (CANADA), INC. (US) | 2017-10-10 | — | — | US | disclosed |