Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.98 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | TNKS | O95271 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1944266 | 1.00 | PARP1 (0.98) | PARP1CCNE2CDK4PRKACAPRKACG | |
| Bromide SCHEMBL1946605 | 0.99 | PARP1 (0.96) | PARP1CCNE2CDK4PRKACAPRKACG | |
| Bromide SCHEMBL1946607 | 0.99 | PARP1 (0.96) | PARP1CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL1946020 | 0.99 | PARP1 (1.00) | PARP1CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL30417469 | 0.99 | PARP1 (1.00) | PARP1CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL1945766 | 0.99 | PARP1 (1.00) | PARP1CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL30090665 | 0.99 | PARP1 (1.00) | PARP1CCNE2CDK4PRKACAPRKACG | |
| SCHEMBL3443321 | 0.99 | PARP1 (1.00) | PARP1CCNE2CDK4PRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL1946669 | 0.98 | PARP1 (0.98) | PARP1CCNE2CDK4PRKACAPRKACG | |
| Hydrochloric Acid SCHEMBL1946668 | 0.98 | PARP1 (0.98) | PARP1CCNE2CDK4PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184282-A1 | NOVEL SALT OF ISOQUINOLINE COMPOUND AND CRYSTAL THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-05-12 | — | — | EP | claimed |
| EP-2184282-B1 | NOVEL SALT OF ISOQUINOLINE COMPOUND AND CRYSTAL THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2014-10-08 | — | — | EP | disclosed |
| US-8309573-B2 | Salt of isoquinoline compound and crystal thereof | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-11-13 | — | — | US | disclosed |
| US-20110130419-A1 | NOVEL SALT OF ISOQUINOLINE COMPOUND AND CRYSTAL THEREOF | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2011-06-02 | — | — | US | disclosed |
| EP-2184282-A1 | NOVEL SALT OF ISOQUINOLINE COMPOUND AND CRYSTAL THEREOF | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130419-A1 | NOVEL SALT OF ISOQUINOLINE COMPOUND AND CRYSTAL THEREOF | IMPDH1, IMPDH2, MTAP | HTR1D 372/4885HTR1B 392/4885PARP1 415/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.