Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 3/20 | 0.43 |
| ▸ | CES1 | P23141 | 3/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | TPMT | P51580 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969673 | 0.85 | HCAR1 (0.53) | HCAR1CES2CES1HCAR2TPMT | |
| SCHEMBL24851931 | 0.79 | HCAR1 (0.55) | HCAR1CES2CES1HCAR2TPMT | |
| SCHEMBL21216527 | 0.77 | CES2 (0.37) | CES2CES1SLC6A3CA12CA1 | |
| SCHEMBL24526877 | 0.76 | HCAR1 (0.48) | HCAR1CES2CES1HCAR2TPMT | |
| SCHEMBL24526872 | 0.76 | HCAR1 (0.44) | HCAR1CES2CES1HCAR2TPMT | |
| SCHEMBL24526964 | 0.75 | HCAR1 (0.43) | HCAR1CES2CES1HCAR2SLC6A3 | |
| SCHEMBL24530541 | 0.75 | HCAR1 (0.43) | HCAR1CES2CES1HCAR2SLC6A3 | |
| SCHEMBL24526585 | 0.75 | HCAR1 (0.43) | HCAR1CES2CES1HCAR2SLC6A3 | |
| SCHEMBL336433 | 0.75 | HCAR1 (0.73) | HCAR1CES2CES1HCAR2TPMT | |
| SCHEMBL157714 | 0.75 | HCAR1 (0.73) | HCAR1CES2CES1HCAR2TPMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9783540-B2 | Substituted tetrahydropyrans as CCR2 modulators | CHEMOCENTRYX, INC. (US) | 2017-10-10 | — | — | US | disclosed |