Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 13/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 13/20 | 0.50 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19443174 | 1.00 | DGAT1 (0.53) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL19443179 | 1.00 | DGAT1 (0.53) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL4622497 | 0.80 | CYP26A1 (0.70) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL8536553 | 0.79 | DGAT1 (0.57) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL10341531 | 0.79 | CYP26A1 (0.59) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL10341498 | 0.75 | DGAT1 (0.54) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL4621871 | 0.75 | CYP24A1 (0.68) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL12978373 | 0.75 | DGAT1 (0.50) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL8535642 | 0.75 | CYP19A1 (0.58) | DGAT1ITGB3ITGA2BCYP26A1CYP19A1 | |
| SCHEMBL5582823 | 0.73 | ITGB3 (0.66) | DGAT1ITGB3ITGA2BCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2916839-B1 | NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-10-11 | — | — | EP | disclosed |