SCHEMBL1944405

SCHEMBL1944405

Cn1c(=O)c2c(ncn2Cc2ccccc2)n(C)c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2B P29275 5/20 1.00
SMN1; SMN2 Q16637 4/20 1.00
RXFP1 Q9HBX9 2/20 1.00
LMNA P02545 2/20 0.78
ALDH1A1 P00352 2/20 0.78
MAPK1 P28482 1/20 0.78
HTT P42858 3/20 0.77
UBE2N P61088 2/20 0.77
GLA P06280 1/20 0.77
L3MBTL1 Q9Y468 1/20 0.77
POLB P06746 1/20 0.74
HIF1A Q16665 1/20 0.74
TSHR P16473 1/20 0.74
ABCC8 Q09428 1/20 0.74
KCNJ11 Q14654 1/20 0.74
PDE1A P54750 1/20 0.71
PDE1B Q01064 1/20 0.71
PDE1C Q14123 1/20 0.71
TP53 P04637 1/20 0.70
CASP1 P29466 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17750785 0.93 LMNA (0.89) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL11014928 0.89 POLB (0.83) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL556216 0.89 SMN1; SMN2 (0.80) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL23974582 0.89 SMN1; SMN2 (0.80) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL17786242 0.87 ALDH1A1 (1.00) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL20561174 0.87 LMNA (1.00) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL20561098 0.87 LMNA (0.80) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL555718 0.87 SMN1; SMN2 (0.76) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL20011033 0.87 SMN1; SMN2 (0.76) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1
SCHEMBL22521806 0.86 SMN1; SMN2 (0.76) ADORA2BSMN1; SMN2RXFP1LMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104744465-A Synthetic method of high-purity high-yield theophylline HEFEI PINGGUANG PHARMACEUTICAL CO LTD 2015-07-01 CN claimed
EP-0222414-A2 Novel organic selenium compounds NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1987-05-20 EP claimed
US-20240392273-A1 FACILITATED DELIVERY OF CONCENTRATED ANTIBODY FORMULATIONS USING HYALURONIDASE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-11-28 US disclosed
EP-3624846-B1 HIGH CONCENTRATION PROTEIN FORMULATIONS WITH REDUCED VISCOSITY INCLUDING A COMBINATION OF NICOTINIC ACID AND TRYOPTOPHAN BHAMIS RES LABORATORY PVT LTD (IN) 2024-08-07 EP disclosed
EP-4401758-A1 FACILITATED DELIVERY OF CONCENTRATED ANTIBODY FORMULATIONS USING HYALURONIDASE Takeda Pharmaceutical Company Limited (JP) 2024-07-24 EP disclosed
CN-118139636-A Delivery of promoted concentrated antibody formulations using hyaluronidase 武田药品工业株式会社 2024-06-04 CN disclosed
US-20240115702-A1 HIGH CONCENTRATION PROTEIN FORMULATIONS WITH REDUCED VISCOSITY Bhami's Research Laboratory, Pvt. Ltd. (IN) 2024-04-11 US disclosed
US-11738082-B2 High concentration protein formulations with reduced viscosity Bhami's Research Laboratory, Pvt. Ltd. (IN) 2023-08-29 US disclosed
WO-2023042096-A1 FACILITATED DELIVERY OF CONCENTRATED ANTIBODY FORMULATIONS USING HYALURONIDASE TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-03-23 WO disclosed
CN-113677678-A Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders 加拉帕戈斯股份有限公司 2021-11-19 CN disclosed
CN-113677679-A Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders 加拉帕戈斯股份有限公司 2021-11-19 CN disclosed
EP-0708781-A1 A 3 ADENOSINE RECEPTOR AGONISTS THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1996-05-01 EP disclosed
EP-0680479-A1 METHOD FOR CONVERTING A XANTHINE RING OR DERIVATIVES THEREOF INTO DIALKYLAMINO-XANTHINE DERIVATIVES S.A. NYCOMED CHRISTIAENS N.V. (BE) 1995-11-08 EP disclosed
WO-1995002604-A1 A3 ADENOSINE RECEPTOR AGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-01-26 WO disclosed
WO-1994017064-A1 METHOD FOR CONVERTING A XANTHINE RING OR DERIVATIVES THEREOF INTO DIALKYLAMINO-XANTHINE DERIVATIVES S.A. NYCOMED CHRISTIAENS N.V. (BE) 1994-08-04 WO disclosed
US-4942143-A Imidazothiadiazine derivatives, and their use as medicaments HOECHST JAPAN LIMITED (JP) 1990-07-17 US disclosed
US-4824955-A ANTITUMOR AGENTS NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1989-04-25 US disclosed
EP-0286041-A1 Imidazothiadiazine derivatives, a process for preparing the same and their use as medicaments HOECHST JAPAN LIMITED (JP) 1988-10-12 EP disclosed
EP-0222414-A2 Novel organic selenium compounds NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1987-05-20 EP disclosed
EP-0222414-A2 Novel organic selenium compounds NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1987-05-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11738082-B2 High concentration protein formulations with reduced viscosity ALB, TTR, MAX ADORA2B 3824/4885SMN1; SMN2 320/4885RXFP1 1610/4885
US-20240115702-A1 HIGH CONCENTRATION PROTEIN FORMULATIONS WITH REDUCED VISCOSITY ALB, TTR, MAX ADORA2B 3824/4885SMN1; SMN2 320/4885RXFP1 1610/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.