Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | TYR | P14679 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18724276 | 0.85 | ABL1 (0.56) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL17400523 | 0.84 | ABL1 (0.70) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL480735 | 0.84 | ABL1 (0.70) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL19448234 | 0.82 | ABL1 (0.65) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL17400600 | 0.79 | ABL1 (0.73) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL18723983 | 0.78 | ABL1 (0.53) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL17386703 | 0.78 | ABL1 (0.55) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL19448229 | 0.77 | PIK3CA (0.44) | HSD17B10ALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL16254980 | 0.77 | ABL1 (0.79) | ABL1RAB9ANPC1HSD17B10ALDH1A1 | |
| SCHEMBL18724406 | 0.77 | ABL1 (0.51) | ABL1RAB9ANPC1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9844549-B2 | 2-aminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-12-19 | — | — | US | disclosed |
| US-20170290824-A1 | 2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170290824-A1 | 2-AMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | CHRM3, CHRM2, TRPM2 | ABL1 2969/4885RAB9A 2245/4885NPC1 4435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.