Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.70 |
| ▸ | RAB9A | P51151 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MPL | P40238 | 1/20 | 0.57 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.56 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17400523 | 0.90 | ABL1 (0.70) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL16254980 | 0.86 | ABL1 (0.79) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL19448234 | 0.85 | ABL1 (0.65) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL480598 | 0.85 | TRPA1 (0.61) | ABL1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL17400600 | 0.84 | ABL1 (0.73) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL19448232 | 0.84 | ABL1 (0.59) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL30439830 | 0.82 | MEN1 (0.74) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL18691881 | 0.82 | MEN1 (0.74) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL18724276 | 0.81 | ABL1 (0.56) | ABL1RAB9ANPC1ALDH1A1HSD17B10 | |
| SCHEMBL18724077 | 0.80 | ALDH1A1 (0.60) | ABL1RAB9ANPC1ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411393-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109287-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-09-30 | — | — | WO | disclosed |