SCHEMBL19448478

SCHEMBL19448478

CNC(=O)c1cc(C(=O)N[C@H](C)C(C)C)cc(C(=O)OC)n1

nearest known ligand 0.50

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 19/20 0.50
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19439128 0.79 ALOX15 (0.50) BRD4L3MBTL1
SCHEMBL10383192 0.78 KDM4E (0.53) BRD4L3MBTL1
SCHEMBL21166994 0.77 TAS1R3 (0.56)
SCHEMBL22593023 0.76 SMN1; SMN2 (0.45)
SCHEMBL19448550 0.74 KDM4E (0.39) BRD4L3MBTL1
SCHEMBL25637866 0.74 TAS1R3 (0.40) BRD4
SCHEMBL2909101 0.73 TAS1R3 (0.47)
SCHEMBL22593122 0.71 BRD4 (0.62) BRD4
SCHEMBL20913836 0.71 BRD4 (0.62) BRD4
SCHEMBL20913832 0.71 BRD4 (0.62) BRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017174621-A1 PYRIDYL DERIVATIVES AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-10-12 WO disclosed