Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 14/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19449288 | 0.81 | ALDH1A1 (0.43) | PIM1KDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL19449560 | 0.81 | KDM5B (0.40) | PIM1KDM4E | |
| SCHEMBL19438258 | 0.73 | JAK2 (0.40) | — | |
| SCHEMBL19438259 | 0.73 | JAK2 (0.40) | — | |
| SCHEMBL21754221 | 0.69 | CSNK2A1 (0.47) | CYP11B1CYP11B2PIM1TLR7KDM4E | |
| SCHEMBL19578966 | 0.68 | KDM4E (0.46) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL19455790 | 0.68 | KDM4E (0.55) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL19438383 | 0.68 | APOBEC3A (0.41) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL19449573 | 0.68 | TP53 (0.47) | KDM4ENPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL20839015 | 0.66 | PIM1 (0.43) | CYP11B1CYP11B2PIM1TLR7PARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176961-A1 | IMIDAZO [1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-10-12 | — | — | WO | disclosed |