Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PSD | A5PKW4 | 2/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19449560 | 0.84 | KDM5B (0.40) | KDM4ECDC7PIM1GSK3BHIPK2 | |
| SCHEMBL19449447 | 0.81 | CYP11B1 (0.39) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL19437906 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL19449402 | 0.80 | ALDH1A1 (0.55) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL19438151 | 0.76 | ALDH1A1 (0.60) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL19449437 | 0.76 | MAPT (0.43) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL19449431 | 0.75 | MEN1 (0.38) | ALDH1A1KDM4EHSD17B10SMN1; SMN2PDE10A | |
| SCHEMBL19449388 | 0.74 | HSD17B10 (0.40) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL19449573 | 0.73 | TP53 (0.47) | ALDH1A1KDM4ENPC1RAB9AHPGD | |
| SCHEMBL19438443 | 0.71 | ALDH1A1 (0.50) | ALDH1A1KDM4ENPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176961-A1 | IMIDAZO [1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-10-12 | — | — | WO | disclosed |