Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | WNT1 | P04628 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19452192 | 0.86 | CRHR1 (0.47) | CRHR1CRHR2ALDH1A1POLBDYRK1A | |
| SCHEMBL21460976 | 0.86 | CRHR1 (0.47) | CRHR1CRHR2ALDH1A1POLBDYRK1A | |
| SCHEMBL21483516 | 0.85 | CRHR1 (0.44) | CRHR1CRHR2ALDH1A1KDM4EPOLB | |
| SCHEMBL19452178 | 0.85 | CD38 (0.51) | CRHR1CRHR2POLBLMNA | |
| SCHEMBL21460970 | 0.85 | CD38 (0.51) | CRHR1CRHR2POLBLMNA | |
| SCHEMBL19455189 | 0.84 | ALDH1A1 (0.67) | CRHR1CRHR2ALDH1A1KDM4EPOLB | |
| SCHEMBL21460951 | 0.84 | CD38 (0.47) | CRHR1CRHR2ALDH1A1POLBDYRK1A | |
| SCHEMBL21461077 | 0.84 | CD38 (0.47) | CRHR1CRHR2POLBDYRK1AWNT1 | |
| SCHEMBL19451996 | 0.84 | CD38 (0.47) | CRHR1CRHR2ALDH1A1POLBDYRK1A | |
| SCHEMBL19452115 | 0.84 | CD38 (0.47) | CRHR1CRHR2POLBDYRK1AWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176962-A1 | PYRROLO[1,2-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS, INC. (US) | 2017-10-12 | — | — | WO | disclosed |