Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | FABP3 | P05413 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945260 | 1.00 | HTR2C (0.38) | HTR2CCYP19A1MEN1KMT2AFABP3 | |
| SCHEMBL1944080 | 0.81 | CYP19A1 (0.46) | HTR2CCYP19A1MEN1KMT2APKM | |
| SCHEMBL12563659 | 0.80 | HTR2C (0.40) | HTR2CCYP19A1MEN1KMT2AALDH1A1 | |
| SCHEMBL12539836 | 0.78 | CFTR (0.46) | ALDH1A1GAA | |
| SCHEMBL1944621 | 0.73 | HTR2C (0.44) | HTR2CCYP19A1MEN1KMT2APKM | |
| SCHEMBL7501162 | 0.67 | CYP19A1 (0.45) | HTR2CCYP19A1MEN1KMT2AFABP3 | |
| SCHEMBL7969548 | 0.67 | CYP19A1 (0.45) | HTR2CCYP19A1MEN1KMT2AFABP3 | |
| SCHEMBL8915255 | 0.64 | MEN1 (0.44) | HTR2CMEN1KMT2AADRA1A | |
| SCHEMBL8398520 | 0.64 | MEN1 (0.44) | HTR2CMEN1KMT2AADRA1A | |
| SCHEMBL8088303 | 0.63 | GAA (0.53) | HTR2CCYP19A1MEN1KMT2APIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507215-A1 | DIPHENYL AZEPINE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-10-10 | — | — | EP | disclosed |
| WO-2011067219-A1 | DIPHENYL AZEPINE DERIVATIVES AS MONOAMINE REUPTAKE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-09 | — | — | WO | disclosed |
| US-20110136787-A1 | DIPHENYL AZEPANE, DIAZEPANE AND OXAZEPANE DERIVATIVES AND USES THEREOF | SCHOENFELD RYAN CRAIG | 2011-06-09 | — | — | US | disclosed |
| US-20110136787-A1 | DIPHENYL AZEPANE, DIAZEPANE AND OXAZEPANE DERIVATIVES AND USES THEREOF | SCHOENFELD RYAN CRAIG | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136787-A1 | DIPHENYL AZEPANE, DIAZEPANE AND OXAZEPANE DERIVATIVES AND USES THEREOF | PTGDR2, PTGDR, TBXA2R | HTR2C 146/4885CYP19A1 219/4885MEN1 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.