Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HHAT | Q5VTY9 | 1/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969548 | 1.00 | CYP19A1 (0.45) | CYP19A1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL8088303 | 0.88 | GAA (0.53) | CYP19A1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL1944080 | 0.79 | CYP19A1 (0.46) | CYP19A1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL7969978 | 0.77 | CTRB1 (0.46) | CYP19A1KMT2AMEN1POLB | |
| SCHEMBL7991029 | 0.77 | CTRB1 (0.46) | CYP19A1KMT2AMEN1POLB | |
| SCHEMBL6844052 | 0.77 | CTRB1 (0.46) | CYP19A1KMT2AMEN1POLB | |
| SCHEMBL8088304 | 0.77 | POLL (0.47) | CYP19A1PKMKMT2AMEN1ALDH1A1 | |
| SCHEMBL8111417 | 0.72 | IDO1 (0.48) | ALDH1A1KDM4EGAAPOLBHTR2C | |
| SCHEMBL10725754 | 0.71 | CYP19A1 (0.52) | CYP19A1KMT2AMEN1KDM4EPOLL | |
| SCHEMBL9692681 | 0.70 | FABP3 (0.40) | CYP19A1PKMKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948483-B1 | FARNESYL TRANSFERASE INHIBITORS | AVENTIS PHARMA SA (FR) | 2002-03-13 | — | — | EP | disclosed |
| US-6218406-B1 | AS ANTITUMOR AND ANTILEUKEMIC AGENTS | AVENTIS PHARMA S.A. (FR) | 2001-04-17 | — | — | US | disclosed |
| US-6124465-A | Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments | RHONE-POULENC S.A. (FR) | 2000-09-26 | — | — | US | disclosed |
| US-6013662-A | ANTITUMOR, ANTICARCINOGENIC AGENTS | RHONE-POULENC RORER S.A. (FR) | 2000-01-11 | — | — | US | disclosed |
| EP-0948483-A1 | FARNESYL TRANSFERASE INHIBITORS | Aventis Pharma S.A. (FR) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998029390-A1 | FARNESYL TRANSFERASE INHIBITORS | RHONE-POULENC RORER S.A. (FR) | 1998-07-09 | — | — | WO | disclosed |