Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 1.00 |
| ▸ | PRMT3 | O60678 | 1/20 | 1.00 |
| ▸ | CARM1 | Q86X55 | 1/20 | 1.00 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 1.00 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 1.00 |
| ▸ | PRMT1 | Q99873 | 1/20 | 1.00 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 1.00 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 1.00 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 1.00 |
| ▸ | F2 | P00734 | 2/20 | 0.55 |
| ▸ | ASIC3 | Q9UHC3 | 2/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29625896 | 1.00 | PRMT5 (1.00) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| Dapi SCHEMBL28176609 | 0.91 | PRMT5 (0.83) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| Dapi SCHEMBL235865 | 0.91 | PRMT5 (0.83) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| Dapi SCHEMBL29350295 | 0.91 | PRMT5 (0.83) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| Dapi SCHEMBL2464378 | 0.90 | PRMT5 (0.81) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| Dapi SCHEMBL94350 | 0.90 | PRMT5 (0.81) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| SCHEMBL29428907 | 0.90 | PRMT5 (0.81) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| Dapi SCHEMBL30442885 | 0.90 | PRMT5 (0.81) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| SCHEMBL14854556 | 0.90 | PRMT5 (0.81) | PRMT5PRMT3CARM1EHMT2PRMT6 | |
| Dapi SCHEMBL1609032 | 0.88 | PRMT5 (0.79) | PRMT5PRMT3CARM1EHMT2PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10465196-B2 | Treatment of C9FTD/ALS by targeting RNA expanded repeat sequences | THE SCRIPPS RESEARCH INSTITUTE (US) | 2019-11-05 | — | — | US | disclosed |
| US-20170292129-A1 | TREATMENT OF C9FTD/ALS BY TARGETING RNA EXPANDED REPEAT SEQUENCES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170292129-A1 | TREATMENT OF C9FTD/ALS BY TARGETING RNA EXPANDED REPEAT SEQUENCES | FUS, RAN, TARDBP | PRMT5 1627/4885PRMT3 943/4885CARM1 1387/4885 |
| US-10465196-B2 | Treatment of C9FTD/ALS by targeting RNA expanded repeat sequences | FUS, RAN, TARDBP | PRMT5 1666/4885PRMT3 980/4885CARM1 1591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.