Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | DDIT3 | P35638 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 5/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28845058 | 0.91 | CA12 (0.48) | CA12CA2CA1CA9ALDH1A1 | |
| Hydrochloric Acid SCHEMBL27999953 | 0.84 | CA12 (0.42) | CA12CA2CA1CA9ALDH1A1 | |
| SCHEMBL5761130 | 0.77 | GAA (0.52) | CA12CA2CA1CA9ALDH1A1 | |
| SCHEMBL518862 | 0.74 | MMP13 (0.43) | RECQLMMP13ADAM17DDIT3MMP1 | |
| SCHEMBL8418962 | 0.73 | CA12 (0.67) | CA12CA2CA1CA9ALDH1A1 | |
| SCHEMBL13983248 | 0.73 | SMN1; SMN2 (0.63) | CA12CA2CA1ALDH1A1RECQL | |
| SCHEMBL28197182 | 0.73 | CA12 (0.50) | CA12CA2CA1CA9ALDH1A1 | |
| SCHEMBL19454666 | 0.73 | CYP11B1 (0.35) | CA12CA2CA1CA9ALDH1A1 | |
| SCHEMBL2149410 | 0.72 | TSHR (0.52) | CA12CA2CA1CA9ALDH1A1 | |
| SCHEMBL2410434 | 0.72 | MMP13 (0.43) | CA12CA2CA1CA9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017175068-A1 | THIAZOLOPYRIDINE DERIVATIVES AS GPR119 AGONISTS | MANKIND PHARMA LTD. (IN) | 2017-10-12 | — | — | WO | disclosed |