Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.61 |
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436802 | 0.91 | HSD17B10 (0.73) | HSD17B10THRBALDH1A1HPGDKDM4E | |
| SCHEMBL19455611 | 0.86 | KDM4E (0.49) | HSD17B10THRBALDH1A1HPGDKDM4E | |
| SCHEMBL19436687 | 0.86 | ALDH1A1 (0.77) | HSD17B10THRBALDH1A1HPGDKDM4E | |
| SCHEMBL29929434 | 0.86 | ALDH1A1 (0.77) | HSD17B10THRBALDH1A1HPGDKDM4E | |
| SCHEMBL19455652 | 0.84 | KDM4E (0.56) | HSD17B10ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL19455204 | 0.81 | KDM4E (0.57) | HSD17B10ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL19455786 | 0.81 | KDM4E (0.52) | HSD17B10ALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL19455195 | 0.81 | HSD17B10 (0.60) | HSD17B10THRBALDH1A1HPGDKDM4E | |
| SCHEMBL19455686 | 0.81 | HSD17B10 (0.55) | HSD17B10THRBALDH1A1HPGDKDM4E | |
| SCHEMBL19455411 | 0.81 | KDM4E (0.52) | HSD17B10ALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176960-A1 | PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-10-12 | — | — | WO | disclosed |