Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19436682 | 0.91 | KDM4E (0.60) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19455475 | 0.87 | KDM4E (0.71) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19455790 | 0.86 | KDM4E (0.55) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19436740 | 0.84 | KDM4E (0.78) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL29929932 | 0.84 | KDM4E (0.78) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19455276 | 0.84 | HSD17B10 (0.61) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19455204 | 0.83 | KDM4E (0.57) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19455786 | 0.83 | KDM4E (0.52) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19436760 | 0.82 | KDM4E (0.58) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 | |
| SCHEMBL19455536 | 0.82 | KDM4E (0.48) | KDM4EHSD17B10ALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017176960-A1 | PYRAZOLO[1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-10-12 | — | — | WO | disclosed |