Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 12/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19456159 | 0.88 | BRD4 (0.39) | BRD4PARP1 | |
| SCHEMBL21649797 | 0.86 | BRD4 (0.43) | BRD4 | |
| SCHEMBL19456080 | 0.85 | RXFP1 (0.38) | RXFP1BRD4PARP1EZH2 | |
| SCHEMBL19456093 | 0.84 | BRD4 (0.39) | BRD4 | |
| SCHEMBL19456305 | 0.83 | BRD4 (0.32) | BRD4PARP1 | |
| SCHEMBL19456090 | 0.82 | BRD4 (0.36) | BRD4 | |
| SCHEMBL19456377 | 0.82 | ALDH1A1 (0.37) | BRD4POLBKDM4EALDH1A1HPGD | |
| SCHEMBL19456084 | 0.82 | PARP1 (0.49) | BRD4PARP1 | |
| SCHEMBL19456310 | 0.81 | BRD4 (0.49) | BRD4 | |
| SCHEMBL19456152 | 0.80 | BRD4 (0.50) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440075-B1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2020-01-29 | — | — | EP | disclosed |
| WO-2017174620-A1 | BENZO[B]FURANS AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-10-12 | — | — | WO | disclosed |